People with restless legs syndrome have an insatiable urge to move their legs almost continuously. This is particularly stressful at night, as the constant leg movements prevent them from sleeping.
The causes of restless legs syndrome are not fully understood, but it is certain that it is a neurological disorder. The neurotransmitter dopamine appears to play a role in the development of the disease.
Patients with restless legs syndrome are often deprived of nutrients that are important for nerve function and healthy sleep. Correcting these deficiencies often produces promising results.
The following nutrients play a potential role in the development of restless legs syndrome:
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Magnesium
Magnesium is very important for the functioning of muscles and nerves. It has an antispasmodic effect; a magnesium deficiency leads to the typical nighttime calf cramps. Magnesium is also important for sleep, as it is involved in the production of the sleep hormone melatonin.
Studies show that magnesium can have a positive effect on restless legs syndrome and has a positive effect on sleep quality. [1] , [2]
Iron
Iron has many functions in the body. It is not only important for the transport of oxygen in the blood, but also for brain and nerve function. Among other things, iron is needed for the formation of the neurotransmitter dopamine.
Too little dopamine in the brain is suspected to be involved in the development of restless legs syndrome. Therefore, a lack of iron could promote restless legs syndrome.
Iron deficiency does indeed appear to be a risk factor for restless legs syndrome. [3] Conversely, iron supplementation may alleviate symptoms in patients with low iron levels. [4] , [5]
Tryptophan
People with restless legs syndrome often suffer from sleep disorders, which contributes significantly to their suffering.
Tryptophan is an amino acid that is needed for the production of the sleep hormone melatonin. People with a poor tryptophan supply are more likely to suffer from sleep problems. [6]
Taking tryptophan can support melatonin production and thus improve sleep quality. [7]
Selenium
Selenium is an important antioxidant that protects cells from free radicals. It also protects nerve cells from oxidative damage. Oxidative stress in nerve cells can potentially impair the production of dopamine, which can promote restless legs syndrome.
Studies show that selenium deficiency is associated with an increased risk of restless legs syndrome. Some small studies suggest that selenium supplementation may help with restless legs syndrome. [8]
B vitamins
B vitamins are also known as nerve vitamins because they are essential for nerve function for many reasons. B vitamins are also needed for the production of the neurotransmitter dopamine.
The study situation is not entirely clear, but some patients with restless legs syndrome do not seem to be well supplied with folic acid (vitamin B9) and vitamin B12 .
Some studies show that supplementing with vitamin B12 and folic acid may relieve restless legs symptoms.
Conclusion: Nutrient deficiencies promote restless legs syndrome
Patients with restless legs syndrome are often not well supplied with iron, magnesium, B vitamins, selenium and tryptophan. These nutrients are important for nerve function and a deficiency can potentially affect restless legs syndrome. Sufferers should make sure they are well supplied with these nutrients.
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[1] https://pubmed.ncbi.nlm.nih.gov/17557494/
[2] https://pubmed.ncbi.nlm.nih.gov/9703590/
[3] https://pubmed.ncbi.nlm.nih.gov/30062860/
[4] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5490383/
[5] https://pubmed.ncbi.nlm.nih.gov/24267148/
[6] https://pubmed.ncbi.nlm.nih.gov/2011617/
[7] https://www.researchgate.net/publication/41577516_Tryptophan_for_refractory_bipolar_spectrum_disorder_and_sleep-phase_delay